Cosegregation Online v2This server performs Full-Likelihood cosegregation analysis (Thompson et al. AJHG 2003) with survival penetrance (Belman et al. GIM 2020).

(1) Input a Gene Symbol :

(2) Upload a Pedigree File :

(3) Define a liability class model (optional)

This webtool provides models for BRCA1,BRCA2,CDH1,MLH1,MSH2,MSH6,NF1,PALB2,PMS2,PTEN,RAD51C,RAD51D,TP53.
ATM,CHEK2,MEN1 associate with moderate (<5 fold) risks of cancer and are inappropriate for cosegregation.
To use the provided model, skip this part. The above Gene Symbol must be one of the supported genes.
To use your own model, do one of the following:
Upload a Relative Risk File :
Upload a Penetrance File:

(4) Advanced options (optional)

Allele Frequency: (Default is 0.0001.)
Break loops: (Input yes will let the program breaks loops for you. Default is no.)
Population: (Default is UK.)
Year range: (1993-1997, 1998-2002, 2003-2007, or 2008-2012. Default is 1998-2002.)
Variant of interest: (when your pedigree file contains more than one genetic variant)

(By clicking this button, you agree that this analysis is for research purpose only.)